Klf14 gene polymorphism
WebHere we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression. National Center for Biotechnology Information
Klf14 gene polymorphism
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WebJan 26, 2024 · Genome-wide association studies identified single nucleotide polymorphisms on chromosome 7 upstream of KLF14 to be associated with metabolic syndrome traits … WebDec 5, 2024 · GWAS (genome-wide association studies) have associated Type 2 Diabetes Mellitus with the single nucleotide polymorphism (SNPs) rs972283 (A/G) of KLF14 gene with in a global population. The most common techniques used to analyze SNPs are time consuming, multi-step process and require expensive instruments. Therefore, in order to …
WebJan 29, 2024 · KLF14 is a master trans-regulatory gene, which is involved in the regulation of several biological processes and cellular pathways. KLF14 regulates several important … WebFeb 26, 2024 · genetic instability of the KLF14 gene has been shown to alter chromosomal expression and increase the risk of developing peptic ulcers and gastric cancer (10).
WebDec 16, 2016 · Finally, genotyping of the rs4731702 (C/T) polymorphism of the KLF14 gene can be of high predictive and interventional value of cardiovascular complications in our, and probably other, populations which have a high prevalence of T2DM. Acknowledgements WebKLF14 is a member of a large family of zinc-finger transcription factors that has been widely studied in embryogenesis, cell proliferation, differentiation, and development. The 18 KLFs described in mammals possess highly conserved cysteine and histidine zinc fingers, critical for recognition and binding to CACCC or CGCCC DNA motifs [ 8] .
WebNew, quick, and inexpensive methods for genotyping KLF14 gene polymorphism through Tetra Primer ARMS-PCR were developed in the present investigation. Sin-gle nucleotide polymorphism (SNP) genotyping needs to be attempted to establish association between the identified SNP with metabolic trait for identification of mo-
WebMay 4, 2007 · Thus, KLF14 is the ninth imprinted retrotransposed gene identified to date and the first protein-coding maternally expressed retrotransposed gene identified in mouse, … broadway smoke shop vape shopWebApr 6, 2024 · Clinical Implications of Krüpple-like Transcription Factor KLF-14 and Certain Micro-RNA (miR-27a, miR-196a2, miR-423) Gene Variations as a Risk Factor in the Genetic … carbohydrates highWebJan 29, 2024 · The severity of the symptoms associated with COVID-19 is highly variable, and has been associated with circulating amino acids as a group of analytes in metabolomic studies. However, for each individual amino acid, there are discordant results among studies. The aims of the present study were: (i) to investigate the association between … carbohydrates histologyWebMay 4, 2007 · We then calculated π values at nonsynonymous and synonymous SNP sites separately and determined that KLF14 had a higher π value than 779 of the 827 genes (94.2%) within each of these sets, revealing that the gene's significant enrichment in SNPs is due to elevated numbers of both synonymous and nonsynonymous polymorphisms. carbohydrates iconWebGene polymorphism studies have revealed that multiple SNPs are implicated in the development of T2DM. Therefore, genetic risk factors of T2DM need to be explored for … carbohydrates how much per dayWebApr 6, 2024 · In summary, our study found polymorphic variations in transcription activator KLF14 and miRNAs 27a and 196a genes as functional polymorphisms, which are … carbohydrates high in fiberWebKLF14 gene has a wide expression in different tissues and has a role in metabolic disorders and cancerous diseases (10). The genetic instability of the KLF14 gene has been shown carbohydrates human body